Repression of sphingosine kinase (SK)-interacting protein (SKIP) in acute myeloid leukemia diminishes SK activity and its re-expression restores SK function
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چکیده
منابع مشابه
Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants.
Sphingosine kinase (SK) catalyses the phosphorylation of sphingosine to generate sphingosine 1-phosphate, which is a second messenger involved in the proliferative responses of mammalian cells. Although the yeast Saccharomyces cerevisiae has similar phosphorylated sphingoid bases which appear to be involved in growth regulation and the response to stress, SK activity had not been previously dem...
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29 Enhanced intrinsic neuronal excitability of hippocampal pyramidal neurons via 30 reductions in the postburst afterhyperpolarization (AHP) has been hypothesized to be a 31 biomarker of successful learning. This is supported by considerable evidence that 32 pharmacological enhancement of neuronal excitability facilitates learning. However, it 33 has yet to be demonstrated that pharmacological ...
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In 2001, Boneh and Franklin presented the first efficient and security-proved identity-based encryption scheme using pairing on elliptic curve. In 2003 Sakai and Kasahara proposed another IBE scheme with pairing, which has the potential to improve performance. Later, Chen and Cheng proved the security of a variant of Sakai and Kasahara’s scheme. While, both the security-provable schemes employ ...
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Spectral Kurtosis (SK) is a statistical approach for detecting and removing radio frequency interference (RFI) in radio astronomy data. In this study, the statistical properties of the SK estimator are investigated and all moments of its probability density function are analytically determined. These moments provide a means to determine the tail probabilities of the estimator that are essential...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2020
ISSN: 0021-9258
DOI: 10.1074/jbc.ra119.010467